What did the recent study examine?
A 2026 pilot clinical study investigated NRPT in 40 healthy women over the age of 35. Thirty-two participants reported symptoms associated with the menopause transition.
Participants took 250 mg of NR and 50 mg of pterostilbene daily for seven days. The researchers assessed self-reported symptoms, urinary estrone and estradiol, and markers related to NAD+ metabolism.
The study was open-label, meaning participants and researchers knew what was being taken. It was also short and did not include a placebo group.
What did the researchers observe?
Among women reporting menopause-transition symptoms, the study observed reductions from baseline in:
- Bloating
- Hot-flash frequency and severity
- Poor sleep
The researchers also reported an increase in the urinary estradiol-to-estrone ratio.
These findings are interesting because they suggest that NRPT may deserve further investigation as a nutritional approach to supporting women during the menopause transition. However, the study does not establish that NRPT treats menopause, replaces hormone therapy, or produces the same result in every woman.
The authors specifically noted that larger, placebo-controlled studies are needed. Read the full study.
What do we know about NRPT and NAD+?
Earlier randomized, placebo-controlled research in 120 adults found that NRPT increased blood NAD+ levels at the tested dose. That study supports the ability of the combination to influence NAD+ biology, but an increase in NAD+ is not the same as proving improved longevity or symptom relief. Read the NRPT NAD+ study.
This distinction matters. A strong scientific explanation should separate:
- What the ingredient does biologically
- What has been observed in human studies
- What remains uncertain
Why combine NR with pterostilbene?
NR provides a nutritional precursor for NAD+ production. Pterostilbene is included because of its antioxidant and cellular-signaling properties.
The combination has been studied as a formula, but the effects of a particular commercial product depend on its exact ingredients, doses, purity, and manufacturing standards.
For this reason, evidence about NRPT should not automatically be treated as proof of every product containing NR and PT.
Where does Epicell fit?
Epicell™ combines NR and pterostilbene with additional botanical compounds selected for cellular-aging research, including standardized scarlet beebalm and procyanidin-rich ingredients.
The goal is to support several interconnected areas of healthy aging:
- NAD+ metabolism
- Cellular resilience
- Oxidative-stress defense
- Epigenetic-age biomarkers
- Long-term vitality
Epicell is designed as a multi-pathway longevity formula. Product-specific claims should always reflect the exact Epicell formulation and the evidence available for that finished product.
Final perspective
NR + pterostilbene is one of the more clinically studied NAD+-support combinations. The latest menopause-transition study is promising, but preliminary.
For women considering NRPT, the most accurate conclusion is:
NRPT is an emerging, clinically studied approach to NAD+ support during the menopause transition, with early research suggesting potential benefits for sleep, hot flashes, and bloating.
It should complement—not replace—professional medical advice, especially for women taking medication, using hormone therapy, or managing a health condition.