Biological age reflects how well your cells are functioning, repairing, and adapting over time — and skin often mirrors that resilience through tone, texture, and recovery from daily stress. In skin biology, changes in DNA methylation and other epigenetic modifications influence gene activity without altering the underlying DNA sequence, shaping how skin cells behave as we age (Dermitzakis et al., Epigenomes, 2025).
Epigenetics — the influence of environment, lifestyle, and nutrition on gene expression — is one of the key molecular links between longevity science and visible beauty. These mechanisms help control skin cell turnover, immune signaling, and structural maintenance in response to continuous internal and external signals (Haykal et al., Int J Dermatol, 2025).
Fibroblasts — the cells responsible for producing collagen and elastin — are particularly sensitive to these signals. As epigenetic regulation shifts with age, fibroblast function changes, contributing to reduced structural support and slower repair in the dermis (Dal Pozzo et al., Biopha, 2024).
A younger biological profile is also associated with more balanced oxidative stress and inflammatory signaling. Oxidative stress — an imbalance between reactive oxygen species and antioxidant defenses — has been linked to accelerated aging in skin cells, including mitochondrial damage and decreased structural integrity of the dermal matrix (Quan, PMC, 2015).
Cellular energy itself plays a significant role. Skin renewal — from barrier repair to collagen synthesis — demands metabolic energy. Mitochondria, the powerhouses of the cell, are central to this process: their functional efficiency influences how well cells carry out repair and turnover, contributing to smoother texture and a more radiant appearance as biological age remains lower (Stout et al., PMC, 2019).
Where targeted nutrition fits in
Paremina’s Ageless Cell was developed around this inside-out perspective. Produced in Switzerland, the formula combines botanical ingredients standardized for polyphenol content with plant-derived bioactive compounds selected on the basis of clinical research.
At the center is the proprietary EpiCell™ complex, evaluated in a 12-week clinical study involving 81 adults aged 45–65. Participants showed stabilization in biological age markers while indicators related to cellular aging slowed by roughly 50%. These findings support broader evidence that nutrition and lifestyle interventions can influence epigenetic markers associated with aging and cellular resilience (Dermitzakis et al., Epigenomes, 2025).
From a beauty perspective, that cellular support matters. Concentrated antioxidants and bioactive plant compounds help protect cells from oxidative stress and support the internal environment that skin cells depend on for repair, structure, and renewal.
Skincare — extended inward
Topical skincare works at the surface. Internal support works at the cellular level where collagen production, inflammatory balance, and repair processes begin. Two capsules as part of a morning routine feel as natural as applying a serum or SPF — a quiet layer of support that complements what you put on your skin.
Think of it as a luxury cream you can’t see, working behind the scenes while you move through your life. Over time, the goal is skin that reflects stronger internal resilience — steady, supported, and visibly well-maintained as the months go by.
References (for editorial citation)
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Dermitzakis, I., et al. (2025). Epigenetics in Skin Homeostasis and Ageing. Epigenomes. Evidence on epigenetic mechanisms regulating skin aging.
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Haykal, D., et al. (2025). Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care. Int J Dermatol. Overview of epigenetics and interventions in skin aging.
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Dal Pozzo, L., et al. (2024). Role of epigenetics in skin aging and geroprotective intervention. Biopha. Insights on epigenetic regulation and fibroblast aging.
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Quan, C. (2015). Age-associated reduction of cell spreading and oxidative stress in human dermal fibroblasts. PMC. Evidence linking oxidative stress, mitochondria, and aging in skin fibroblasts.
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Stout, R. (2019). Mitochondria’s role in skin ageing. PMC. Mitochondrial involvement in oxidative damage and aging phenotypes.